Possibilities of intraoperative laparoscopic nephrobiopsy for diagnostics of latent kidney diseases.

Introduction. Chronic kidney disease (CKD) is a worldwide problem with an increasing general and widespread incidence affecting people of all age groups races. All stages CKD are at risk some somatic diseases, reduced quality life mortality. Material methods. The study included 30 patients (16 men 14 women) who underwent surgical treatment intraoperative biopsy to identify possible morphological predictors development in the Urology Department Krasnoyarsk Regional Clinical Hospital. Operations were performed laparoscopically for cysts, stenosis pyelo-ureteral segment, neoplasms. from anamnesis data did not have glomerular lesions. ranged 21 79 years. Directly obtained tissues using puncture processing 16G guillotine needle intraoperatively under visual control. Tissue columns obtained, separated light-optical microscopy, immunofluorescence reaction, electron microscopy. Posting samples studies was carried out according standard method. Results. Based on results nephrobiopsies during laparoscopic operations kidney, latent lesions diagnosed first time 6.7% moderate or severe manifestations tubulo-interstitial nephritis 33.3%. In addition, mesangial proliferation tubular atrophy 63.3% specimens. Conclusion. Intraoperative work-controlled nephrobiopsy safe method assessing morphofunctional state renal parenchyma, which allows one-time urological load identification phenomena preclinical manifestations.